Evaluation of Anxiolytic Activity of Hydroalcoholic Activity of Tephrosia Purpuria (l) Pers on Swiss Albino Mice

The present work is to evaluate the anxiolytic activity of a hydroalcoholic extract of Tephrosia purpuria (L) Pers (HAETP) in mice using the elevated plus-maze (EPM), elevated zero-maze (EZM), Y-maze and hole-board models. Furthermore, the anxiolytic effects of HAETP were compared to a known active anxiolytic drug diazepam. The extract, administered orally, in two different doses of HAETP 200 mg/kg and 400 mg/kg, was able to increase the time spent and the number of arm entries in the open arms of the elevated plus-maze and elevated zero-maze, as well as decrease the visits by mice in the Y-maze, also significantly increase nose poking, line crossing and rearing in hole-board. This effect was comparable to that of the diazepam (2.0 mg/kg i.p.). These results indicate that hydroalcoholic extract Tephrosia purpuria (L) Pers is an effective anxiolytic agent.